diff --git a/scripts/pylib/twister/twisterlib.py b/scripts/pylib/twister/twisterlib.py
index b7672d4efc..5386c94f8f 100755
--- a/scripts/pylib/twister/twisterlib.py
+++ b/scripts/pylib/twister/twisterlib.py
@@ -718,9 +718,10 @@ class DeviceHandler(Handler):
                 serial_line = ser.readline()
             except TypeError:
                 pass
+            # ignore SerialException which may happen during the serial device
+            # power off/on process.
             except serial.SerialException:
-                ser.close()
-                break
+                pass
 
             # Just because ser_fileno has data doesn't mean an entire line
             # is available yet.